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Transgender Youth: Endocrine Considerations
Compelling studies have demonstrated that “gender identity” — a person’s inner sense of self as male, female, or occasionally a category other than male or female — is not simply a psychosocial construct, but likely reflects a complex interplay of biological, environmental, and cultural factors. An increasing number of...
Bone Mass, Bone Geometry, Body Composition in FtM after Long-Term Hormonal Therapy
Context: Female-to-male transsexual persons (transsexual men) undergo extreme hormonal changes due to ovariectomy and testosterone substitution, allowing studies on sex steroid effects on bone geometry and physiology in the adult. Objective: The objective of the study was to examine the effects of cross-gender sex s...
Endocrine Treatment of Transsexual People: Guidelines
Objective: The aim was to formulate practice guidelines for endocrine treatment of transsexual persons. Participants: An Endocrine Society-appointed Task Force of experts, a methodologist, and a medical writer. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment...
Effect of Long-Term Administration of Hormonal Therapy on Serum and Urinary Uric Acid
Background: Transsexual persons afford a very suitable model to study the effect of sex steroids on uric acid metabolism. Design: This was a prospective study to evaluate the uric acid levels and fractional excretion of uric acid (FEUA) in a cohort of 69 healthy transsexual persons, 22 male-to-female transsexuals (M...
Prevalence of Polycystic Ovary Syndrome and Hyperandrogenemia in FtM
Introduction: It has been postulated that the prevalence of polycystic ovary syndrome (PCOS) in female-to-male transsexuals (FMTs) is higher than normal. Aim: The aim of the study was to investigate the prevalence of PCOS and hyperandrogenemia in FMTs, compared with controls. Methods: Sixty-one FMTs were evaluate...
Long-Term Treatment of Transsexuals with Cross-Sex Hormones: Personal Experience
Context: Transsexuals receive cross-sex hormone treatment. Its short-term use appears reasonably safe. Little is known about its long-term use. This report offers some perspectives. Setting: The setting was a university hospital serving as the national referral center for The Netherlands (16 million people). Pati...
Le traitement hormonal des patients transsexuels et ses conséquences métaboliques
Lorsque le diagnostic de transsexualité est établi selon les critères du DSM-IV, le patient peut débuter un traitement hormonal et ainsi développer les caractères sexuels secondaires du sexe choisi. La thérapeutique est de type androgénique chez les patients F–M et de type estrogénique chez les patients M–F. Ces traite...
Long-Term Administration of Testosterone Undecanoate in FtM
Context: The most common treatment regimen in female-to-male transsexuals is administration of short-acting testosterone esters im every 2 wk. Objective: Our objective was to report the effects of administering long-acting testosterone undecanoate every 3 months on hormonal and clinical changes, mortality, morbidity...
Endocrine Treatment of Transsexual People: A Review of Treatment
Cross-sex hormone treatment is an important component in medical treatment of transsexual people. Endocrinologists are often faced with designing treatment recommendations. Although guidelines from organizations, such as the Harry Benjamin International Gender Dysphoria Association, have been helpful, management rema...
Observations cliniques de l’effet du changement de climat hormonal
Communication faite au 33e Séminaire de Perfectionnement en Sexologie Clinique de l’AIHUS (4 au 6 avril 2003, Montpellier). “Masculin-Féminin et comportements : Influence de l’ambiance hormonale ?” Table ronde animée par Hervé Lejeune et Jacques Rollet. Dr Juliette Buffat, Médecin-psychiatre et sexothérapeute Rés...
Breast Tissues in Transsexual Women: A Nonprostatic Source of Androgen
The present study made use of the female transsexual model and sought to evaluate the contributions of the ovarian, endometrial, and breast tissues to the androgen up-regulated production of prostate specific antigen (PSA). Serum levels of PSA were significantly raised in female transsexuals before surgery, after long-...
Effects of Sex Steroids on Plasma Total Homocysteine Levels
Plasma total homocysteine (tHcy) levels are higher in men vs. premenopausal women, but it is not known whether this difference is related to sex steroids. The effects of cross-sex hormone administration on plasma tHcy levels were therefore investigated. Plasma tHcy levels were measured at baseline and after 4 months of...